Projects
2024 - Present. Integrated Assessment of Vascular Function Using NIRS and Brachial Artery FMD
This study aims to comprehensively assess vascular health by integrating near-infrared spectroscopy (NIRS) and brachial artery flow-mediated dilation (FMD) analysis. NIRS provides real-time monitoring of tissue oxygenation and hemoglobin levels, offering insights into tissue perfusion dynamics. Concurrently, FMD, assessed via ultrasound, evaluates endothelial function—a critical indicator of vascular health. By combining these modalities, the study seeks to correlate tissue oxygenation with endothelial function, providing a deeper understanding of vascular physiology and potentially enhancing diagnostic and treatment strategies for cardiovascular and vascular diseases. My role in this project is to develop and advance the experimental methods, conduct the experiments, and analyze the data.
2020 - 2024. Continuous Noninvasive Monitoring of the Placental Oxygenation during Pregnancy
My objective is to conduct research aimed at creating secure, non-invasive, and portable equipment that can evaluate placental oxygenation to establish a standardized oxygenation dataset that can be correlated with pregnancy outcomes. The focus of this study is on assessing baseline oxygenation in both laboring and non-laboring patients, as well as in patients with pregnancy-related complications. To achieve this goal, I have developed a near-infrared spectroscopy (NIRS) device that can monitor oxygen saturation and am currently exploring a technique for identifying placental oxygen saturation using this device. Additionally, I am undertaking a parallel study that investigates the connection between placental oxygen saturation and the dynamic behavior of cells at the cellular level by analyzing the concentration of oxygen using Dynamic Full-field Optical Coherence Tomography.
2019 - 2020. Study on Elastic Modulus and Non-contact Intraocular Pressure Measurement Techniques Based on Multi-phase Optical Interferometer
A surface acoustic wave (SAW) was generated in the imitated eye with a pulsed laser and the waveguide characteristics of the SAW were investigated. My aim was to devise a non-invasive method for measuring intraocular pressure by leveraging the SAW detection technique in conjunction with a multi-phase optical interferometer. As part of this endeavor, I designed a system capable of detecting the elastic characteristics of SAW signals by employing a 3×3 optical fiber coupler.
2018 - 2019. Development of Phase-complementary Non-contact Photoacoustic Bio-imaging System
The purpose of this study was to undertake a comprehensive analysis of reconstructing photoacoustic images through a non-invasive approach. The primary objective was to simulate the image of the photoacoustic signal as it propagates through a sample and then reconstruct and image the signal detected through experimental procedures. In order to visualize the photoacoustic signal, I developed a system that leverages the property that the index of the media changes by the photoacoustic signal propagates, and I was responsible for visualizing the signal.
2017. Noncontact Photoacoustic Microscopy Using Full-field Optical Coherence Tomography (OCT)
Conventional photoacoustic microscopy/tomography is a system that sequentially captures internal images of a biological sample using a contact-type ultrasound probe. One of the drawbacks of photoacoustic imaging is its reliance on physical contact with the sample, which can cause contamination, and its application is limited by the need for index-matched media. In addition, temporal resolution is low because signal detection is performed sequentially. To solve these problems, we built a system capable of acquiring high-resolution optoacoustic images based on a full-field optical coherence imaging system. As part of this project, I designed a full-field OCT system configuration and devised an acoustic measurement algorithm utilizing signal triggering.
2015 - 2017. Development of a non-invasive blood glucose measurement method using photoacoustic technology based on an optical interferometer
The aim of this project was to design an optical interferometer signal processing algorithm and detect photoacoustic signals on the skin’s surface. As part of this project, I built the configuration of the photoacoustic signal generation system for blood glucose and formulated the algorithm for detecting the signal.
2014 - 2017. Fiber Distributed Acoustic Sensor (DAS) Technology Research for Acoustic wave Detection and Analysis
The purpose of this project is to study the basic technology of DAS to detect the presence, location, and type of adjacent moving objects using optical fiber backscatter signals. DAS is a technology for long-range monitoring using a single optical fiber, and can be used for security, oil and/or gas pipeline abnormality detection, etc. In this project, I was assigned the role of analyzing the characteristics of an object using a backscattered signal into the optical fiber.